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In these cases, Plavix on top of aspirin has been shown to save lives, and going off the medication could lead to a clot and serious harm or death, the college and leading physicians said.

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They will not break up existing blood clots, and should not be used by individuals with bleeding problems like hemophillia or ulcers.

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The study, presented Sunday at an American College of Cardiology meeting in Atlanta, suggested that taking Plavix on top of aspirin to prevent a heart attack may raise the risk of death in a subset of people who have no clogged arteries but conditions such as high blood pressure and high cholesterol.